I'd say start with the basics such as oil change, new air filter, spark plugs, plug wires etc. Check also for exhaust leaks, exhaust back pressure, vacuum leaks, proper tire inflation and being that it's a 99' you might want to try and get a scan tool hooked up just to see how your overall engine is performing. I've got a 99' K1500 and I believe they were only rated at 11/15 city/hwy so anything above that is great. You may even want to change all your fluids to synthetics. Just my 2 cents.