The faster you drive the more fuel you will use.. Also, were you using E85 fuel? Lots of complaining about mileage in some parts of the country and its suspected its due to increased Ethanol content in the fuel. The more the ethanol, the lower the mileage because Ethanol has less energy in it.
This could be just an isolated event for that reason...
I just this week made a 500 mile round trip over to Duluth, MN with a 2010 Sierra E. Cab SLT Z71 All Terrain, 5.3L and loaded. I got 17.7 mpg and about 100 of those miles I drove in AUTO 4x4 due to snow and ice covered roads.