I would go with the 4.3L some of the earlier vortec engines had problems with the fuel injector leaking. It has a single injector with six legs coming off of it. when I was a mechanic we called it a spider. I'm sorry I don't remember what years were bad but I know around 1999 they fixed the problem. The vortec is a More powerful engine and more fuel efficient as well. I knew a guy who put a 350 in a S10 and he had a real nightmare making it work. When he got it done he was talking about poring concrete in the bed because he couldn't keep the wheels from spinning.